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10685738 Cancer diagnostic tool using cancer genomic signatures to determine cancer type  
Cancer types (e.g., organ/tissue of origin and/or cancer subtype for an organ/tissue) can be distinguished by applying statistical methods to data samples consisting of counts of somatic single...
10684290 LKB1 related diagnostics and treatments of cancer  
Described herein are methods and compositions for the diagnosis, prognosis, selection of treatment and treatment of cancer, and particularly, of lung cancer such as non-small cell lung cancer....
10684285 Diagnostics of gyneacological diseases, especially epithelial ovarian cancer  
The present disclosure relates to methods and a kit for diagnosing, prognosing and/or monitoring a gynaecological disease, especially epithelial ovarian cancer, on the basis of altered...
10683550 HNF4G-RSPO2 fusion gene and use thereof in treatment of cancer  
The present disclosure provides methods of detecting a fusion gene of HNF4G and RSPO2 in a nucleic acid-containing sample, and a primer set, a probe set and a kit for detecting the fusion gene are...
10683549 Methods for assessing risk of developing breast cancer  
The present disclosure relates to methods and systems for assessing the risk of a human female subject for developing breast cancer. In particular, the present disclosure relates to combining...
10683506 CD117 ligand-drug conjugates for targeted cancer therapy  
Disclosed are compositions and methods relating to nucleic acid aptamers that specifically target CD117 protein and also selective binding to CD117-expressing cells. The ligand-drug conjugates...
10683352 Methods for treating cancer using GRM8 inhibitors  
The present invention provides methods for treating cancer using mGluR8 inhibitors, such as mGluR8 inhibitory antibodies and small molecules. The invention also features compositions containing...
10683347 Treatment of cancer using anti-TGF-β and anti-PD-1 antibodies  
The present disclosure relates, in general, to combination therapy using an inhibitor of transforming growth factor beta (TGFβ) and an inhibitor of programmed cell death protein 1 (PD-1) for...
10683337 Peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10683304 Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer  
Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or...
10683286 Furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer  
A furazan-3-carboxylic acid derivative or pharmaceutically acceptable salt thereof for treatment of acute myeloid leukemia.
10683284 Compounds for preventing, inhibiting, or treating cancer, aids and/or premature aging  
The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or premature aging. The compounds of...
10683269 2-cyanoisoindoline derivatives for treating cancer  
The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition...
10682421 Nanoparticle composition for use in targeting cancer stem cells and method for treatment of cancer  
There is disclosed a composition in the form of a nanoparticle. The nanoparticle composition has a diameter from 5 to 500 nanometers. The nanoparticle composition has i) a central core portion...
10682420 Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane  
The present invention relates to methods and kits for the treatment of breast cancer based on hormone receptor status of progesterone receptor and estrogen receptor comprising the administration...
10682411 Saposin C pharmaceutical compositions and methods of treating cancer  
Disclosed are pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.
10682402 MSI-specific frameshift peptides (FSP) for prevention and treatment of cancer  
Described is a vaccine for prevention and treatment of cancer characterized by microsatellite instability (MSI). The vaccine contains an MSI-specific frameshift peptide (FSP) generating humoral...
10682401 Multi-indication mRNA cancer immunotherapy  
Synthetic bacterial messenger RNA can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mRNA obtained...
10682400 Combination vaccine devices and methods of killing cancer cells  
The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects...
10682399 Target peptides for colorectal cancer therapy and diagnostics  
A set of target peptides are presented by HLA A*0201, B*0301, B*0702 and B*2705 on the surface of disease cells. They are envisioned to, among other things, stimulate an immune response to the...
10682390 Compositions and methods for treating cancer  
Use of a CXCR4 antagonistic peptide and an immune-check point regulator in the treatment of cancer is provided. Accordingly there is provided a method of treating cancer in a subject in need...
10682388 Targeting of PELP1 in cancer therapy  
The disclosure describes PELP1 binding peptides and peptoids and their use the interaction of PELP1 with molecules that lead to oncogenic signaling in cancers.
10682356 Combination therapies for treatment of cancer  
Combination therapies for treatment of cancer are provided. The disclosed methods comprise administration of a cyclin-dependent kinase inhibitor and a DNA methyltransferase inhibitor to a mammal...
10682353 Varlitinib for use in the treatment of resistant or refractory cancer  
The present disclosure provides a method of treating a patient with refractory or resistant cancer by administering a therapeutically effective amount of a compound of formula (I), such as...
10682348 Molecules for administration to ROS1 mutant cancer cells  
Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical...
10682339 Pharmaceutical compositions directly targeting FKBP52 for the treatment of prostate cancer and methods of using same  
Embodiments of the current invention include methods and compositions for regulating the activity of hormone receptors.
10679752 System and method for computing survivorship risk associated with delaying therapy in breast cancer  
An estimate is made of a time since a given presenting cancer would have first been detectable using a known diagnostic technique, and an estimate is also made of initial characteristics of the...
10679730 Prognostic and predictive breast cancer signature  
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating a specified set of genes. Specifically, methods may comprise calculating...
10677801 Diagnosis and treatment of breast cancer  
The present invention relates to compositions and methods for-determining a treatment course of action. In particular, the present invention relates to compositions and methods for the prediction...
10677800 Biomarkers for diagnosis and prognosis of lung cancer  
Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels...
10676792 Prognostic and diagnostic methods for colorectal cancer  
Provided herein are methods for selecting a drug therapy for a patient with cancer, such as colorectal cancer, pancreatic cancer, lung cancer or breast cancer. The method includes determining or...
10676531 Anti-CD43 antibody and use thereof for cancer treatment  
Provided is an antibody for treating a cancer, more specifically, an anti-CD43 antibody binding to an extracellular domain of CD43, compositions for treating a cancer or inhibiting a cancer stem...
10676487 Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer  
The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria...
10676480 Anti-cancer compounds targeting Ral GTPases and methods of using the same  
Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the...
10675338 Peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10675337 Cancer vaccine for cats  
The present invention provides a nucleic acid, or an immunogenic composition thereof, that comprises a sequence encoding a cat telomerase deprived of telomerase catalytic activity, or a fragment...
10675326 Compositions comprising cupredoxins for treating cancer  
The present invention discloses methods and materials for killing and/or inhibiting the growth of a cancer cell via preferential entry of a cytotoxic compound. Preferential entry of the cytotoxic...
10675304 Combination immunotherapies for treatment of cancer  
Described herein are compositions and methods for treating a disease, particularly a cancer, with an immune checkpoint modulatory agent and a strain of an Arbovirus or a strain of an Alphavirus....
10675303 Extracellular matrix compositions for the treatment of cancer  
The present invention is directed to methods of inhibiting cancer cell growth or proliferation by contacting the cancer cell with an extracellular matrix (ECM) composition. Also provided are...
10675289 Methods of treating pancreatic cancer  
Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. The methods...
10675262 Development of dietary therapy in cancer  
The invention provides new compositions or combinations thereof for the treatment of cancer. More specifically, the invention provides compositions or combinations thereof for cancer treatment...
10675257 Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent  
The present invention relates to a composition for use in treating a glioma or ameliorating the effects of a glioma, particularly glioblastoma, wherein said composition comprises a first active...
10671885 Cancer diagnostic method and system  
A method and system for classifying tissue suspected of being abnormal as being malignant or benign. The method includes generating a set of selection features, performing statistical applications...
10670603 Diagnosis and treatment of cancer expressing ILT3 or ILT3 ligand  
The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand...
10669589 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments  
Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will...
10669588 Methods for sub-typing and treating cancer  
This invention relates to a novel approach for the identification and stratification of subtypes of cancer, particularly pancreatic ductal adenocarcinoma (PDAC). The invention furthermore relates...
10669584 Cancer antigen-specific T-cell receptor gene, peptide encoded by the gene, and use of them  
Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or...
10669536 Diagnosis of prostate cancer  
The invention provides methods for isolating RNA from whole urine and urine fractions for the diagnosis of prostate cancer and/or benign prostate hyperplasia. An exemplary method for diagnosing...
10669349 Compositions and methods for treatment of cancer  
Compositions, e.g., compositions comprising cellular therapeutics and/or protein therapeutics, and methods of using such compositions for treating cancer are described.
10669326 Peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...

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